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RCCC Treatment of Burns and Inflammation,
Healing without Scarring, Skin Replacement Projects
| Clinical Challenges |
Project |
Proposed Therapies |
| Burn inflammation and injury extension; Scarring; Wound infection |
Therapies to limit injury progression, control inflammation, prevent infection, and promote non-scar healing after burns and battle trauma |
Intravenous therapy; Bone marrow-derived mesenchymal stem cells (MSCs); topical therapies |
| Scarring |
Adipose-derived therapies for wound healing, tissue repair and scar management |
Adipose-derived therapies for accelerating wound healing and minimizing scarring
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Skin loss in burn wounds when autografts are not immediately available
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Burn repair with skin substitutes cultured from the patient's own cells |
Permanent, engineered, adjunct to traditional skin grafts for treatment of extensive, deep burns
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Therapies to Limit Injury Progression, Control Inflammation, Prevent Infection, and Promote Non-scar Healing After Burns and Battle Trauma
Improved management of burn wounds aims to minimize both the immediate problems associated with burns and the long-term functional impairment, usually caused by scarring.
The RCCC team is tackling the progression of burn injury – both its severity and its extent – by developing both intravenous and surface wound treatments. The intravenous treatments use combinations of drugs and cells. The surface treatments depend on biomaterials in the form of novel bandages or gels that incorporate drugs known to penetrate the skin.
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Detail of absorbable patch to prevent
burn injury progression
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Stony Brook University, Center of Tissue Engineering, Richard Clark, MD
Stony Brook University, Department of Emergency Medicine, Adam Singer, MD
Case Western Reserve University, Skeletal Research Center, Arnold Caplan, PhD
Northwestern University, Wound Healing Research Laboratory, Thomas Mustoe, MD
Rutgers, New Jersey Center for Biomaterials, Joachim Kohn, PhD |
Adipose-Derived Therapies for Wound Healing, Tissue Repair and Scar Management
Adipose tissue- fat- is a plentiful source of tissue and stem cells that are easily harvested, expendable, and readily replenished. Human adipose stem cells produce a wide variety of factors that positively impact the repair of damaged tissues by modulating inflammation, blood vessel development, cell death, cell migration and cell proliferation. The Katz group is leveraging the vast potential of this particular source of tissue to improve the outcomes of severely wounded warriors.
Autologous fat transfer (transplantation of the patient's own fat tissue) is currently in clinical trials to assess: 1) whether autologous fat transfer will prevent severe scarring and, 2) to determine whether the technique can favorably remodel scars older than 6 months.
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Adipose-Tissue-derived stem cells
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University of Virginia, Chronic Wound Care Clinic, Laboratory of Applied Developmental Plasticity, Adam Katz, MD
Wound Healing Research Laboratory, Northwestern University, Director, Thomas Mustoe, MD
University of Cincinnati, Department of Surgery, Department of Biomedical Engineering, Stephen Boyce, PhD
Tribeca Plastic Surgery, Sydney Coleman, MD Rutgers, New Jersey Center for Biomaterials, Joachim Kohn, PhD |
Burn Repair with Skin Substitutes Cultured from the Patient’s Own Cells
Restoration of the body’s largest organ and its first rampart of self‐defense‐ the skin‐ following extensive blast or burn injury is a limiting step in the wounded warrior’s recovery. Traditional techniques for burn closure rely on grafting portions of remaining skin to other sites. Often there is too little skin remaining for harvest compared with the large area requiring coverage.
To fill this need, the Boyce group has:
-Developed a permanent (autologous) two‐layered
engineered skin substitute (ESS).
-Conducted clinical trials demonstrated decreased
need for harvesting remaining skin when using ESS.
Further clinical trials are planned to initiate in late 2010 in order to advance the ESS.
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ESS success
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University of Cincinnati, Departments of Surgery and Biomedical Engineering, Steven Boyce
University of Cincinnati, Department of Surgery, Dorothy Supp
United States Army Surgical Institute, San Antonio, TX
Lonza Walkersville, Inc., Cell Therapy Division, Kim Warren
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